Farelerde yapılan deneysel siyatik sinir kesisinde nifedipinin sinir rejenerasyonu üzerine olan etkilerinin incelenmesi










































































when we compared the distal latance results of ENMG in control group in means of difference between the sciatic nerve cut legs exposed to saline ( mean 2,28 0,55) and normally legs ( mean 1,30 0,25) with Paired t test. Spontaneous healing and signal transduction functions were not reached to the normal limits. According to the ENMG distal latance results in nifedipine treated group, the difference between sciatic nerve cut legs ( mean 1,50 0,27) and normally legs ( mean 1,16 0,16) are conserved with Paired t test ( p < 0,001 ), so we detected that there was also no complete healing in nifedipine group. However, when we compared distal latance results of the saline applied and nifedipine applied sciatic nerve cut legs in both nifedipine (mean 1,50 0,27) and control group (mean 2,28 0,55) with Student t test; better healing in nifedipine group than control group according to the p < 0,001 value was detected. In immunocytochemical examination of the control group which drug wasnt used after the cutting of sciatic nerve , there were too many disorganized axons in cutting region which couldnt be reached to the aim . In the nifedipine group , axons were less than control group but there were organized axons which were reached to the aim . Neurinoma formation in sciatic nerve was seen in six mice in control group but not in nifedipine group. In conclusion , we determined the positive effect of nifedipin on the peripheral nerve regeneration. Many experimental and clinical comparative studies are needed to prove the positive effect of this drug in the peripheral nerve regeneration. 5



10. SAYFAYA BENZER SAYFALAR

Periferik sinir yaralanmalarının onarımında kollojen biyomatriks ve omentum greftinin sinir rejenerasyonu üzerine etkilerinin karşılaştırılması - Sayfa 90
87 VII. SUMMARY Remarkable amount of experimental work regarding basic behavior of the neuron after injury and have been described. However, nerve injuries still represent a major problem. We aimed to study the effect of tissudura (Baxter, Vienna, Austria) and omentum graft, which has concentrated growth factors in peripheral nerve healing. Thirty-five male Wistar rats, weighing between 180 to ...
Ratlarda perition içine verilen folik asitin tamir edilen tibial sinir iyileşmesine etkisi(Deneysel çalısma) - Sayfa 74
SUMMARY THE EFFECT OF INTRAPERITONEALLY ADMİNİSTERED FOLİC ACİD ON THE REPAİRED TIBİAL NERVE HEALİNG IN RATS Objective: Despite considerable advances in treating peripheral nerve injury, complete nerve regeneration and clinic healing is currently impossible. In this study, we investigated the effect of intraperitoneal folic acid on nerve healing in rat peripheral nerve repair model. Material an...

10. SAYFADAKI ANAHTAR KELIMELER

peripheral
control
group
that
were
nerve


10. SAYFA ICERIGI

when we compared the distal latance results of ENMG in control group in means of difference between the sciatic nerve cut legs exposed to saline ( mean 2,28 0,55) and normally legs ( mean 1,30 0,25) with Paired t test. Spontaneous healing and signal transduction functions were not reached to the normal limits. According to the ENMG distal latance results in nifedipine treated group, the difference between sciatic nerve cut legs ( mean 1,50 0,27) and normally legs ( mean 1,16 0,16) are conserved with Paired t test ( p < 0,001 ), so we detected that there was also no complete healing in nifedipine group. However, when we compared distal latance results of the saline applied and nifedipine applied sciatic nerve cut legs in both nifedipine (mean 1,50 0,27) and control group (mean 2,28 0,55) with Student t test; better healing in nifedipine group than control group according to the p < 0,001 value was detected. In immunocytochemical examination of the control group which drug wasnt used after the cutting of sciatic nerve , there were too many disorganized axons in cutting region which couldnt be reached to the aim . In the nifedipine group , axons were less than control group but there were organized axons which were reached to the aim . Neurinoma formation in sciatic nerve was seen in six mice in control group but not in nifedipine group. In conclusion , we determined the positive effect of nifedipin on the peripheral nerve regeneration. Many experimental and clinical comparative studies are needed to prove the positive effect of this drug in the peripheral nerve regeneration. 5

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