ABSTRACT
Cabuk N, Effıcacy of angıotensın receptor blocker candesartan and betablocker metoprolol on mıgraine headache. Zonguldak Karaelmas University, Faculty of Medicine, Thesis in Neurology, Zonguldak 2007. A variety of drugs from diverse pharmacological classes are in use for migraine prevention. In this study we aimed to compare the preventive effect of two drugs; metoprolol and candesartan on the frequency and intensity of migraine attacks. 50 patients diagnosed as migraine with or without aura according to IHS (International Headache Society) criteria in outpatient clinic of Neurology Department of Zonguldak Karaelmas University, Faculty of Medicine were enrolled into study. Patients were divided into two groups (25 each) similar in gender, age, and pain characteristics. In one group candesartan 16mg daily, and in the second group metoprolol 50mg daily were chosen as the preventive drugs. All patients were followed-up regularly with their headache diaries on the first, thirth and sixth months of therapy. Efficacy measures included frequency, intensity, duration, and adverse events. Frequency, intensity (VASVisual Analog Scale) and duration of migraine attacks were found significantly lower on the first, third and sixth month follow-up examinations than pretreatment examinations in candesartan and metoprolol groups. Ratio of the patients with 50% or lower attack frequency and duration compared with the pretreatment scores were 52.4% in the two groups. 4 patients dropped out of the study because of adverse events in each group. No statistical difference was found on the sixth month headache frequency, duration and intensity scores of the two groups. This study demonstrates that Candesartan an Angiotensin II reseptor blocker is effective and reasonably well tolerated as the first line drug metoprolol when used for the preventive treatment of migraine. In migraine patients with comorbid bronchial, kardiak or psychiatric disease that does not allow to use beta blockers, candesartan is a new effective, safe and well tolerated alternative therapy.
Key words: headache, migraine, prophilaxis, beta-blocker, anjiotensin II receptor blocker, metoprolol, candesartan
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5. SAYFAYA BENZER SAYFALAR

Kronik migren hastalarında venlafaksin ve topiramat tedavisinin karşılaştırılması - Sayfa 6
ABSTRACT THE COMPARISON OF VENLAFAXINE AND TOPIRAMATE TREATMENT IN PATIENTS WITH CHRONIC MIGRAINE Chronic migrane treatment is not worked so much, also it is a problematic issue and a small number of randomized trails on this subject is available. The aim of this study is to compare effectiveness of drugs which include venlafaxine and topiramate in patients diagnosed with chronic migraine. Patien...
Migren ve menstruel migren ataklarının 24 saatlik doğal seyri - Sayfa 12
ABSTRACT BEKDEMİR ÖZÜAK, Özlem. The Natural Course of Migraine and Menstrual Migraine Attacks Through 24 Hours. Kirikkale University, Faculty of Medicine, Department of Neurology. Thesis of Speciality, 2010 The aims of the study were to evaluate the natural courses and responses to naproxen sodium and frovatriptan treatment of the migraine and menstrual migraine attacks (MM). The patients in tw...
Migreni olan okul çalışanlarında migren tedavisinin özürlülük ve ekonomik kayıp üzerine etkisi: - Sayfa 6
SUMMARY The Effect of Treatment of Migraine on Headache-Related Economic Burden ond Workplace Productivity omong Migraineurs Employed in School: A Prospective Study Migraine and other primary headaches should not be perceived as a pain-related condition but should be evaluated in the light of their results on health sector and the society as whole. Migraine imposes an important economical and s...

5. SAYFADAKI ANAHTAR KELIMELER

migraine
patients
with
headache
were
attack


5. SAYFA ICERIGI

ABSTRACT
Cabuk N, Effıcacy of angıotensın receptor blocker candesartan and betablocker metoprolol on mıgraine headache. Zonguldak Karaelmas University, Faculty of Medicine, Thesis in Neurology, Zonguldak 2007. A variety of drugs from diverse pharmacological classes are in use for migraine prevention. In this study we aimed to compare the preventive effect of two drugs; metoprolol and candesartan on the frequency and intensity of migraine attacks. 50 patients diagnosed as migraine with or without aura according to IHS (International Headache Society) criteria in outpatient clinic of Neurology Department of Zonguldak Karaelmas University, Faculty of Medicine were enrolled into study. Patients were divided into two groups (25 each) similar in gender, age, and pain characteristics. In one group candesartan 16mg daily, and in the second group metoprolol 50mg daily were chosen as the preventive drugs. All patients were followed-up regularly with their headache diaries on the first, thirth and sixth months of therapy. Efficacy measures included frequency, intensity, duration, and adverse events. Frequency, intensity (VASVisual Analog Scale) and duration of migraine attacks were found significantly lower on the first, third and sixth month follow-up examinations than pretreatment examinations in candesartan and metoprolol groups. Ratio of the patients with 50% or lower attack frequency and duration compared with the pretreatment scores were 52.4% in the two groups. 4 patients dropped out of the study because of adverse events in each group. No statistical difference was found on the sixth month headache frequency, duration and intensity scores of the two groups. This study demonstrates that Candesartan an Angiotensin II reseptor blocker is effective and reasonably well tolerated as the first line drug metoprolol when used for the preventive treatment of migraine. In migraine patients with comorbid bronchial, kardiak or psychiatric disease that does not allow to use beta blockers, candesartan is a new effective, safe and well tolerated alternative therapy.
Key words: headache, migraine, prophilaxis, beta-blocker, anjiotensin II receptor blocker, metoprolol, candesartan
v

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