7. SAYFAYA BENZER SAYFALAR
tabs_sener_yagiz_191898 - Sayfa ...
7. SAYFA ICERIGI
COMPARISON OF CHRONIC HEPATITIS C PATIENTS WITH NORMAL AND HIGH AMINOTRASFERASE LEVELS IN TERMS OF
HISTOPATHOLOGICAL AND BIOCHEMICAL PARAMETERS (What Should the Range of Normal Alanine Aminotransferase be?)
About 30% of untreated patients with chronic HCV infection have normal ALT levels (1,2). Significant liver damage has been found in a remarkable part of these patients although they continuously present normal ALT levels (3). Many new studies investigate whether previous levels that define normal ALT reference range are valid in these patients (4,5). In this study, we aimed to compare chronic hepatitis C patients with normal ALT levels to patients with elevated ALT levels in terms of clinical, biochemical, virological and histological features and also to determine which ALT threshold value is associated with histological damage according to the obtained data and which ALT level can show chronic hepatitis.
A total of 36 patients (24 women, 12 men) with chronic HCV infection were examined before treatment with antiviral drugs. These patients included in the study were separated into two groups as normal patients and patients with elevated transaminase. 12 patients (11 women, 1 man) were included to normal ALT group, 24 patients (13 women, 9 men) were included to the group with elevated ALT and chronic hepatitis C. In our study, 16 healthy volunteers with ages and genders suitable for each other were included as control group in order to determine a threshold level for ALT patients with chronic hepatitis C infection.