SUMMARY SERUM ALANINE AMINOTRANSFERASE LEVELS AND THE FACTORS ASSOCIATED WÄ°TH ALANINE AMINOTRANSFERASE LEVELS IN HEALTHY SUBJECTS Aim: In recent years, many studies about the normal serum Alanine aminotransferase (ALT) levels have been reported. In these studies, it has been investigated whether the normal levels and the upper limits (UNL) of ALT are different from the currently used values and which potential factors are associated with ALT levels. The purpose of this study was to determine the UNL of serum ALT levels and the factors associated with serum ALT levels in appearently healthy subjects. Methods: A total of 884 healthy subjects were included in the study. Serum ALT, fasting blood glucose and cholesterol levels were measured. Normal ranges and UNL for ALT were computed in the group of subjects with the lowest liver disease risk. Univariate and multivariate analyses were performed to determine the factors associated with the ALT levels. Results: Serum ALT levels were independently associated with sex and body mass index whereas there were no association with age, fasting blood glucose and cholesterol levels. UNL for serum ALT levels in males and females were computed as 19,9 IU/L and 31,47 IU/L respectively. Conclusion: Because serum ALT levels in healthy subjects is associated with sex, UNL for serum ALT levels in males and females should be defined seperately. In our study, UNL for ALT levels were determined to be lower than the current values. However, in order to make a firm desicion for the revision of UNL for ALT levels, we need further studies based on larger populations. x
SUMMARY SERUM ALANINE AMINOTRANSFERASE LEVELS AND THE FACTORS ASSOCIATED WÄ°TH ALANINE AMINOTRANSFERASE LEVELS IN HEALTHY SUBJECTS Aim: In recent years, many studies about the normal serum Alanine aminotransferase (ALT) levels have been reported. In these studies, it has been investigated whether the normal levels and the upper limits (UNL) of ALT are different from the currently used values and which potential factors are associated with ALT levels. The purpose of this study was to determine the UNL of serum ALT levels and the factors associated with serum ALT levels in appearently healthy subjects. Methods: A total of 884 healthy subjects were included in the study. Serum ALT, fasting blood glucose and cholesterol levels were measured. Normal ranges and UNL for ALT were computed in the group of subjects with the lowest liver disease risk. Univariate and multivariate analyses were performed to determine the factors associated with the ALT levels. Results: Serum ALT levels were independently associated with sex and body mass index whereas there were no association with age, fasting blood glucose and cholesterol levels. UNL for serum ALT levels in males and females were computed as 19,9 IU/L and 31,47 IU/L respectively. Conclusion: Because serum ALT levels in healthy subjects is associated with sex, UNL for serum ALT levels in males and females should be defined seperately. In our study, UNL for ALT levels were determined to be lower than the current values. However, in order to make a firm desicion for the revision of UNL for ALT levels, we need further studies based on larger populations. x
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