VIII ABSTRACT EFFECT OF MAGNESIUM LEVEL TO THE DEVELOPMENT OF DELIRIUM IN INTENSIVE CARE UNIT Delirium is a reversible disorder of consciousness with an acute onset ranging from hours to days and a course with disruptions and fluctuations of cognitive functions. The neurotransmitters that control the cognitive functions, personality and affect of an individual have been shown to be inactivated in delirium, and the balance in their synthesis and release is abolished. In general, delirium is caused by changes in neurotransmitter levels, with an increase in dopamin, and decrease in asetylcholine. Delirium is a a state not to be neglected which can cause severe consequences that is related to criticall illness in intensive care unit with acute cerebral dysfunction. Clinical features of delirium include impairments of consciouness, thinking, memory, psychomotor behaviour, perception and emotion. Pharmacological approaches in treatment, certain side-effects of current drugs bring along alternative theraphy researches. Delirium is divided into motoric subtypes, namely the hypoactive, hyperactive and mixed typed. The mixed type is characterized by hypoactive and hyperactive periods. The first scale developed for intubated patients in intensive care units, namely the Intensive Care Delirium Screening Checklist has a sensitivity of %99, and a moderate specificity of %64. Currently Confusion Assessment Method for Ä°ntensive Care Units (CAM-ICU) is more commonly employed. In treatment of delirium, drugs stabilizing the brain functions via antagonizing dopamine neurotransmissions in bazal ganglia and synapses elsewhere in the brain are recommended. Magnesium sulphate plays an important role in a lot of physical phenomen on affecting brain. The serum levels at intravenouse administration is predictable and high levels are well-tolerated. Becoming a neuroprotective agent, magnesium sulphate is effective on regulating the major neurotransmitter functioning in sympathetic and parasympathetic nervous system. In our study we investigated the concentration of magnesium levels of patients in ICU with delirium and under sedation. Estimating with CAM-ICU and RASS scoring systems the days that delirium ocurred and did not occur we surveyed for the relevance
VIII ABSTRACT EFFECT OF MAGNESIUM LEVEL TO THE DEVELOPMENT OF DELIRIUM IN INTENSIVE CARE UNIT Delirium is a reversible disorder of consciousness with an acute onset ranging from hours to days and a course with disruptions and fluctuations of cognitive functions. The neurotransmitters that control the cognitive functions, personality and affect of an individual have been shown to be inactivated in delirium, and the balance in their synthesis and release is abolished. In general, delirium is caused by changes in neurotransmitter levels, with an increase in dopamin, and decrease in asetylcholine. Delirium is a a state not to be neglected which can cause severe consequences that is related to criticall illness in intensive care unit with acute cerebral dysfunction. Clinical features of delirium include impairments of consciouness, thinking, memory, psychomotor behaviour, perception and emotion. Pharmacological approaches in treatment, certain side-effects of current drugs bring along alternative theraphy researches. Delirium is divided into motoric subtypes, namely the hypoactive, hyperactive and mixed typed. The mixed type is characterized by hypoactive and hyperactive periods. The first scale developed for intubated patients in intensive care units, namely the Intensive Care Delirium Screening Checklist has a sensitivity of %99, and a moderate specificity of %64. Currently Confusion Assessment Method for Ä°ntensive Care Units (CAM-ICU) is more commonly employed. In treatment of delirium, drugs stabilizing the brain functions via antagonizing dopamine neurotransmissions in bazal ganglia and synapses elsewhere in the brain are recommended. Magnesium sulphate plays an important role in a lot of physical phenomen on affecting brain. The serum levels at intravenouse administration is predictable and high levels are well-tolerated. Becoming a neuroprotective agent, magnesium sulphate is effective on regulating the major neurotransmitter functioning in sympathetic and parasympathetic nervous system. In our study we investigated the concentration of magnesium levels of patients in ICU with delirium and under sedation. Estimating with CAM-ICU and RASS scoring systems the days that delirium ocurred and did not occur we surveyed for the relevance
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